Current IIBI research investigates the pathology of many eye diseases, including diabetic retinopathy, macular degeneration, macular holes, epiretinal membranes, macular edema, central serous choroidopathy, and of the optic disc, combining state of the art imaging modalities like optical coherence tomography with our well-established segmentation approaches.

Ophthalmic image analysis is performed by the following mutually collaborating groups at IIBI:

Abrámoff, Kwon, Sonka Team


Michael D. Abramoff

Professor of Ophthalmology and Visual Sciences


Young H. Kwon

Professor of Ophthalmology and Visual Sciences

Milan Sonka portrait

Milan Sonka

IIBI Co-Director

Retinal image analysis of 3D OCT - Iowa Reference Algorithms

Left-to-right: OCTExplorer 3.8.0 (stable); OCTExplorer 5.0.0 (beta).

Choroid analysis from 3D OCT

3D choroidal vessel segmentation. Left-to-right: Central B-scan (XY) image; en-face (XZ) image; 3D rendering.

Glaucoma - Assessing visual function from 3D OCT

Left: actual and predicted 24-2 Humphrey visual field (HVF) pairs for 97 patients with early, morderate or advanced primary and secondry open angle glaucoma. Middle: Correlation of actual and predicted HVF at each test location, except locations at ONH, with predictors for each test location optimized based on retinal ganglion cell axonal complex (RGC-AC). Right: Optimized NFL path (green) for each predicted test location (red).

Age-related Macular Degeneration from 3D OCT

3D symptomatic exudate-associated derangements (SEADs) segmentation. Left-to-right: Central B-scan (XY) image; en-face (XZ) image; 3D rendering of retinal surfaces and SEADs; 3D rendering of SEADs.

ONH analysis from 3D OCT

Optic disc segmentation (red: optic cup, green: neuroretinal rim). Left-to-right: Central B-scan image; OCT projection image; 3D rendering of the retinal surfaces textured using OCT projection image; registered fundus image; 3D rendering of the retinal surfaces textured using registered fundus image.

​Garvin, Kardon Team


Mona Garvin

Professor, Electrical and Computer Engineering


Randy H. Kardon

Professor of Ophthalmology and Visual Sciences

  • Peripapillary OCT image analysis
    • Optic nerve head
    • Papillodema

The University of Iowa Institute for Vision Research

Genetic aspects of ophthalmic diseases

IIVR Website